Corticosteroids Management of Crohn's disease

steroid enemas can used treatment of rectal disease symptoms

corticosteroids class of anti-inflammatory drugs used treat moderate severe flares of crohn s disease. however, used sparingly because can cause serious side effects, including cushing s syndrome, mania, insomnia, hypertension, high blood glucose, osteoporosis, , avascular necrosis of long bones. corticosteroids should not confused anabolic steroids used enhance athletic performance.

the commonly prescribed oral steroid prednisone, typically dosed @ 0.5 mg/kg induction of remission in crohn s disease. intravenous steroids, administered in hospital setting, used when oral steroids not work or cannot taken. because corticosteroids reduce body s ability fight infection, care must taken ensure there no active infection, particularly intra-abdominal abscess, before initiation of steroids.

another oral corticosteroid, budesonide (trade name entocort), has limited absorption , high level of first-pass metabolism, meaning lower quantities of drug enter bloodstream. has been shown useful in treatment of mild moderate crohn s disease, , in maintaining remission. effective when used in combination antibiotics treat active crohn s disease. budesonide released in ileum , right colon, , therefore has topical effect against disease in area.

steroid enemas can used treat symptoms in lower colon , rectum. hydrocortisone , budesonide liquid , foam enemas marketed purpose.