Cases of exposure 2,3,7,8-Tetrachlorodibenzodioxin

viktor yushchenko chloracne after tcdd poisoning incident

there have been number of incidents people have been exposed high doses of tcdd or combination of tcdd , other dioxin-like chemicals, including:

in 1976, thousands of inhabitants of seveso, italy exposed tcdd after accidental release of several kilograms of tcdd pressure tank. number of animals died, , high concentrations of tcdd, 56,000 pg/g of fat, noted in children playing outside , eating local food. acute effects limited 200 cases of chloracne. long-term effects seem include slight excess of multiple myeloma , myeloid leukaemia, developmental effects such disturbed development of teeth , excess of girls born fathers exposed children. several other long-term effects have been suspected, evidence not strong.
in vienna, 2 women poisoned @ workplace in 1997, , measured concentrations in 1 of them highest ever measured in human being, 144,000 pg/g of fat. 1 hundred thousandfold compared tcdd concentrations in people today, , ten thousandfold compared sum of dioxin-like compounds in young people today. survived suffered difficult chloracne several years. poisoning happened in october 1997, not discovered until april 1998. @ institute women worked secretaries, high concentrations of tcdd found in 1 of labs, suggesting compound had been produced there. police investigation failed find clear evidence , no 1 ever prosecuted. aside malaise , amenorrhea there surprisingly few other symptoms or abnormal laboratory findings.
in 2004, then-presidential candidate viktor yushchenko of ukraine poisoned large dose of tcdd. blood tcdd concentration measured 108,000 pg/g of fat, second highest ever measured. concentration implies dose exceeding 2 mg, or 25 μg/kg of body weight. suffered chloracne many years, again after initial malaise, other symptoms or abnormal laboratory findings few.
an area of polluted land in italy, known triangle of death, contaminated tcdd due years of illegal waste disposal organized crime.




^ p. mocarelli; et al. (1991). serum concentrations of 2,3,7,8- tetrachlorodibenzo-p-dioxin , test results selected residents of seveso, italy . j. toxicol. environ. health. 32 (4): 357–366. doi:10.1080/15287399109531490. pmid 1826746. 
^ cite error: named reference pesatori invoked never defined (see page).
^ cite error: named reference alaluusua invoked never defined (see page).
^ p. mocarelli; et al. (2000). paternal concentrations of dioxin , sex ratio of offspring . lancet. 355 (9218): 1858–63. doi:10.1016/s0140-6736(00)02290-x. pmid 10866441. 
^ cite error: named reference sweeney invoked never defined (see page).
^ a. geusau; k. abraham; k. geissler; m.o. sator; g. stingl; e. tschachler (2001). severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) intoxication: clinical , laboratory effects . environ. health perspect. 109 (8): 865–9. doi:10.1289/ehp.01109865. pmc 1240417 . pmid 11564625. 
^ sorg, o.; zennegg, m.; schmid, p.; fedosyuk, r.; valikhnovskyi, r.; gaide, o.; kniazevych, v.; saurat, j.-h. (2009). 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) poisoning in victor yushchenko: identification , measurement of tcdd metabolites . lancet. 374 (9696): 1179–85. doi:10.1016/s0140-6736(09)60912-0. pmid 19660807. 
^ senior, k; mazza, (sep 2004). italian triangle of death linked waste crisis . lancet oncol. 5 (9): 525–7. doi:10.1016/s1470-2045(04)01561-x. pmid 15384216. 
^ il triangolo della morte . rassegna.it. march 2007. retrieved 2008-09-26. 
^ discariche piene di rifiuti tossici quello è il triangolo della morte . la repubblica. 2004-08-31. retrieved 2008-09-26.