Antiquity Antakya
the area of antioch has been occupied humans since calcolithic era (6th millennium bc), revealed archeological excavations of mound of tell-açana, among others.
the king of macedon alexander great, after defeating persians in battle of issus in 333 bc, followed orontes south syria , occupied area. city of antioch founded in 300 bc, after death of alexander, hellenistic seleucid king seleucus nicator. played important role 1 of largest cities in hellenistic seleucid kingdom, in roman empire , in byzantium, , key city during years of christianity, , of syriac orthodox church, antiochian orthodox church, , since 7th c. ad rise of islam, , after 10th c. ad crusades.
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