Types Single-nucleotide polymorphism

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types of single-nucleotide polymorphism (snps)


single-nucleotide polymorphisms may fall within coding sequences of genes, non-coding regions of genes, or in intergenic regions (regions between genes). snps within coding sequence not change amino acid sequence of protein produced, due degeneracy of genetic code.


snps in coding region of 2 types: synonymous , nonsynonymous snps. synonymous snps not affect protein sequence, while nonsynonymous snps change amino acid sequence of protein. nonsynonymous snps of 2 types: missense , nonsense.


snps not in protein-coding regions may still affect gene splicing, transcription factor binding, messenger rna degradation, or sequence of non-coding rna. gene expression affected type of snp referred esnp (expression snp) , may upstream or downstream gene.







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